Neuroprotective role of intermittent fasting in senescence-accelerated mice P8 (SAMP8)
نویسندگان
چکیده
منابع مشابه
Muscle mass, structural and functional investigations of senescence-accelerated mouse P8 (SAMP8)
Sarcopenia is an age-related systemic syndrome with progressive deterioration in skeletal muscle functions and loss in mass. Although the senescence-accelerated mouse P8 (SAMP8) was reported valid for muscular ageing research, there was no report on the details such as sarcopenia onset time. Therefore, this study was to investigate the change of muscle mass, structure and functions during the d...
متن کاملNo effects of lifelong creatine supplementation on sarcopenia in senescence-accelerated mice (SAMP8).
Oral creatine supplementation can acutely ameliorate skeletal muscle function in older humans, but its value in the prevention of sarcopenia remains unknown. We evaluated the effects of lifelong creatine supplementation on muscle mass and morphology, contractility, and metabolic properties in a mouse model of muscle senescence. Male senescence-accelerated mice (SAMP8) were fed control or creati...
متن کاملSingle nucleotide variants (SNVs) define senescence-accelerated SAMP8 mice, a model of a geriatric condition.
One of the major challenges in neurodegenerative research is modeling systemic aging. Here, senescence-accelerated mice such as the multigenic SAMP8 (senescence accelerated prone 8) mice are useful as they are characterized by an early manifestation of senescence that includes a shortened lifespan and impaired brain and immune functions. While SAMP8 mice are widely used tools to address aging a...
متن کاملModulation of Signal Transduction Pathways in Senescence-Accelerated Mice P8 Strain: A Useful Tool for Alzheimer’s Disease Research
José Luis Albasanz1, Carlos Alberto Castillo1,2, Marta Barrachina3,4, Isidre Ferrer3,4,5 and Mairena Martín1 1Departamento de Química Inorgánica, Orgánica y Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Ciudad Real 2Departamento de Enfermería, Facultad de Terapia Ocupacional, Logopedia y Enfermería, Universidad de Castilla-La...
متن کاملExtracts of Cistanche deserticola Can Antagonize Immunosenescence and Extend Life Span in Senescence-Accelerated Mouse Prone 8 (SAM-P8) Mice
The senescence accelerated mouse prone 8 substrain (SAM-P8), widely accepted as an animal model for studying aging and antiaging drugs, was used to examine the effects of dietary supplementation with extracts of Cistanche deserticola (ECD) which has been used extensively in traditional Chinese medicine because of its perceived ability to promote immune function in the elderly. Eight-month-old m...
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ژورنال
عنوان ژورنال: Experimental Gerontology
سال: 2010
ISSN: 0531-5565
DOI: 10.1016/j.exger.2010.04.010